Self renewal: 10 hard facts πŸ™Œ

Hello everyone πŸ––

1. The human body in which each of us lives is made up of around 37 trillion cells, to be precise. And every day, about 1-2 percent of the cells are renewing. So, exactly after 90–100 days, a new “me” appears. We remain so busy with our routine lives that we hardly acknowledge this fact, and many of us are not even aware of it. So, β€˜change’ is the constant tune, not just within the universe but also within us.

2. Now that we understand that our bodies undergo transformation on a daily basis, So, the question is: how does this self-renewal occur? Let’s go back to our past a little bit. The human body develops from the human embryo, which is fertilized by an oocyte and a sperm cell. This embryo is made up of stem cells. The stem cells are the basic cells (undifferenciated cells) of the human body, which, through the process of mutation and transformation grow into different cells like nerve cells, bone cells, muscle cells, blood cells and so on. Throughout our lifespan, these stem cells undergo cell division and keep replicating; that’s how self-renewal happens.

3. Under normal physiological self-renewal processes, different cells in the body have differing rates of cell division. So, the replication process of various tissues, organs, and blood cells in the body has a different time frame, like the skin epidermal cells, which can take around 10–30 days, whereas a bone cell takes 3 months, or a hair grows about 1 cm in one month, and so on.

4. Though our body is constantly changing due to the continuous self-renewal process through different cell cycles like shedding the old skin cells, renewal of intestinal cell lining, and growing hair or nails on a routine basis, this isn’t a simpler process. The human body is still very complicated and has exceptions. Some cells, such as those in the brain (cerebral cortex), eyes (such as lenses), and heart, do not change from birth to death.

5. But then, why is self-renewal important and must be maintained? Under normal physiological conditions, stem cells have two functions: proliferation and differentiation. Though stem cells have a natural proliferative capacity throughout our lives, disease conditions can affect their physiological self-renewal ability and behavior due to factors such as damage or an unhealthy lifestyle (obesity, lack of physical activity, smoking, or a poor diet).

6. A lack of an appropriate environment within the body or poor maintenance of the human body might eventually lead to the exhaustion of the capacity of stem cell proliferation, which causes premature aging or tissue atrophy. With aging, stem cell activity, tissue regenerative and haemeostasis is significantly declined.

7. Sometime, due to the unhealthy environment within the body, mutations lead to aggressive stem cell division without going through the natural cell differentiation process. This can lead to abnormal tissue growth or cancer in the body. Therefore, the physiological process of stem cell division and the natural stem cell behavior can be affected by four disease conditions, like degenerative, metabolic, cardiovascular, and inflammatory conditions.

8. Regenerative medicine and therapies have arisen as a result of the discovery that defective self-renewal mechanisms in the body are the root cause of malignancies and abnormal cell proliferation. Many disorders are being treated with regenerative medicines based on stem cells. Recent years have seen a significant increase in the use of stem cell treatment to treat a variety of diseases like cancer and disorders including type 1 diabetes, heart disease, stroke, Parkinson’s, burns, osteoarthritis, by regenerating cells, repairing tissues, and transplanting organs.

9. The fact about regenerative medicine is that, though it has helped many patients around the world, the cost of treatment is quite high as the procedure is complicated and the failure rate is high. Human stem cell treatment requires culturing human stem cells in a laboratory setting for a longer period of time, which is quite difficult.

10. The market is flooded with products that promote cell regeneration, anti-aging, and longevity. The lofty claims made by these items are still quite dubious. But it is true that some supplements do work to improve health, lower inflammation, and increase immunity. But in the end, having a healthy diet, getting enough sleep, a calm mind, and exercising regularly is all that’s necessary for good health.

Thanks for reading.

Peace and love πŸ™

All about Puffy eyes πŸ™„

Hello everyone ! Have a wonderful and safe weekend πŸ™‹πŸ»

Maybe, we all at some point or very often been troubled with puffiness around eyes, especially below the eyes, interfering with our looks. Puffy eyes are seen usually in the age group above 30 to 40 years. But, nowadays, often young people are also seen with puffy eyes. So, it very common among all age groups. Structurally, eyes are surrounded by orbital fats on all sides that protect the eyes from any external injury and help smooth eyeball movement on all sides. There is also an orbital septum between the orbital bone and the eyelid, preventing orbital fat from bulging. As we age, this orbital septum gets weaker and weaker, and hence the puffiness can be prominent.

Since it is found in both young and aged, the causes are plenty. It can be temporary or persistent, mild to severe depending upon the underlying cause. Sometimes, puffiness can be idiopathic that is without any known cause. Transient puffiness is mostly seen after waking up in the morning, which can disappear as the day progresses. In most of the people, it can be persistent, as the ageing process moves. It can be in varying degree ranging from mild, moderate to severe. The different probable causes can be :

1. Allergy like due to allergens like dust, pollen, dander.
2. Infection in the eyes like conjunctivitis, which can cause both pink and puffy eyes.
3. Wearing contact lenses for too long can cause puffiness as the cornea gets swelled up due to cut off oxygen supply while the lenses are on.
4. Ageing is the most typical cause as the orbital fat below the eyes slowly start protruding.


5. Too much alcohol intake causes bloating.
6. Not getting enough sleep.
7. Too much salt consumption causes water retention.


8. Too much artificial sugar, or high sugar diet can cause water retention, inflammation and bloat.
9. Kidney issues and when protein intake is high. There is an electrolyte imbalance, more sodium in the body. So, there is water retention.
10. Thyroid causes.
11. Cirrhosis as liver problems can cause bloating.
12. Crying for too long can cause transient puffiness.

Depending upon the cause and the severity, the remedies and treatment are required.

1. If it is a mild kind of puffiness, and due to a temporary cause like eye injury, not getting enough sleep, high salt consumption or high alcohol intake. Correcting the underlying cause and applying a cold compress or caffeine creme can be very helpful.

2. If it is due to a medical cause like thyroid issues, kidney issues or liver Cirrhosis, the individual needs to make lifestyle changes like – low carbohydrate diet, low protein diet, cutting down salt and sugar. Sometimes, increasing potassium content through dietary sources can help to get rid of the excess fluid. And, of course, treating the underlying cause with medication.
3. Cosmetic reasons: Sometimes, due to the ageing process, the puffiness can be severe and hinder the physical appearence. In such cases, Hyualuronic acid fillers and lower eyelid blepheroplasty can be helpful.

Thanks for reading.

Blessings and much love to all πŸ’